MolNFT v1 · #62983 · protein
Crystal structure of the gdf-5:BMP receptor ib complex.
3EVS · GROWTH/DIFFERENTIATION factor 5: “Crystal structure of the gdf-5:BMP receptor ib complex.”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #62983 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3EVS
- Type
- protein
- Length
- 189 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GROWTH/DIFFERENTIATION factor 5; Bone morphogenetic protein receptor type-1B
- UniProt
- P43026, P36898
- Pockets
- 1 · best druggability 0.30
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | GROWTH/DIFFERENTIATION factor 5 | protein | 104 | 20% helix, 45% strand | P43026 |
| C | Bone morphogenetic protein receptor type-1B | protein | 85 | 9% helix, 35% strand | P36898 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.30 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- B–C · 376 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3EVS · Crystal structure of the GDF-5:BMP receptor IB complex. · the same entry in another collection · chain B against B, TM-score 1.00
- P43026 · AlphaFold monomer V2.0 prediction for GROWTH/DIFFERENTIATION factor 5 (P43026) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P36898 · AlphaFold monomer V2.0 prediction for bone morphogenetic protein receptor type-1B (P36898) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43026
- Every structure of UniProt P36898
- Elsewhere: RCSB PDB 3EVS · PDBe 3EVS · UniProt P43026 · UniProt P36898
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