MolNFT v1 · #62982 · protein
Crystal structure of calcium bound monomeric GCAMP2
3EVR · Myosin light chain kinase, green fluorescent protein…: “Crystal structure of calcium bound monomeric GCAMP2”. X-ray diffraction, 2 ligands (CRO, CA), 1 pocket (best druggability 0.82). MolNFT v1 #62982 on GenesisL1: 3D structure…
- PDB
- 3EVR
- Type
- protein
- Length
- 397 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin light chain kinase, green fluorescent protein, calmodulin-1 chimera
- UniProt
- P42212, P0DP29
- Ligands
- CRO, CA
- Pockets
- 1 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin light chain kinase, green fluorescent protein, calmodulin-1 chimera | protein | 397 | 33% helix, 31% strand | P42212, P0DP29 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 767 | 0.82 | 0.85 | 94 | CRO |
Modifications
Observed in the structure: 2 cofactor (chromophore).
Compared structures
- 3EVR · Crystal structure of Calcium bound monomeric GCAMP2 · the same entry in another collection · chain A against A, TM-score 1.00
- P42212 · AlphaFold monomer V2.0 prediction for green fluorescent protein (P42212) · a predicted model of the same protein · chain A against A, TM-score 0.37
- P0DP29 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP29) · a predicted model of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42212
- Every structure of UniProt P0DP29
- Elsewhere: RCSB PDB 3EVR · PDBe 3EVR · UniProt P42212 · UniProt P0DP29
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