MolNFT v1 · #62954 · protein

Crystal structure of the FGFR2 D2 domain

3EUU · Fibroblast growth factor receptor 2: “Crystal structure of the FGFR2 D2 domain”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #62954 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3EUU
Type: protein
Length: 200 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor receptor 2
EC: 2.7.10.1
UniProt: P21802
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Fibroblast growth factor receptor 2 (EC 2.7.10.1)	protein	100	13% helix, 52% strand	P21802

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.38	0.78	13	empty
2	80	0.38	0.77	13	empty

Interfaces

1 interface between chains.

A–B · 514 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3EUU · Crystal structure of the FGFR2 D2 domain · the same entry in another collection · chain A against A, TM-score 1.00
P21802 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 2 (P21802) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21802
Elsewhere: RCSB PDB 3EUU · PDBe 3EUU · UniProt P21802

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