MolNFT v1 · #62931 · protein

Crystal structure of a PALB2 / BRCA2 complex

3EU7 · Partner and localizer of BRCA2: “Crystal structure of a PALB2 / BRCA2 complex”. X-ray diffraction, 2 pockets (best druggability 0.75). MolNFT v1 #62931 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3EU7
Type: protein
Length: 327 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Partner and localizer of BRCA2; 19MERIC peptide from breast cancer type 2 susceptibility…
UniProt: Q86YC2, P51587
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 2% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Partner and localizer of BRCA2	protein	313	0% helix, 58% strand	Q86YC2
X	19MERIC peptide from breast cancer type 2 susceptibility protein	protein	14	36% helix, 0% strand	P51587

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	852	0.75	0.79	63	empty
2	50	0.37	0.80	18	GOL

Interfaces

1 interface between chains.

A–X · 600 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

3EU7 · Crystal Structure of a PALB2 / BRCA2 complex · the same entry in another collection · chain A against A, TM-score 1.00
Q86YC2 · AlphaFold monomer V2.0 prediction for partner and localizer of BRCA2 (Q86YC2) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q86YC2
Every structure of UniProt P51587
Elsewhere: RCSB PDB 3EU7 · PDBe 3EU7 · UniProt Q86YC2 · UniProt P51587

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.