MolNFT v1 · #62650 · protein

Structure of cystationine gamma lyase

3ELP · Cystathionine gamma-lyase: “Structure of cystationine gamma lyase”. X-ray diffraction, 13 pockets (best druggability 0.77). MolNFT v1 #62650 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ELP
Type: protein
Length: 1,372 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cystathionine gamma-lyase
EC: 4.4.1.1
UniProt: P32929
Pockets: 13 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A, C, D	Cystathionine gamma-lyase (EC 4.4.1.1)	protein	343	40% helix, 18% strand	P32929

Pockets

13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	542	0.77	0.84	66	empty
2	540	0.77	0.84	60	empty
3	540	0.76	0.83	61	empty
4	574	0.76	0.83	62	empty
5	512	0.67	0.78	62	empty

Interfaces

3 interfaces between chains.

B–A · 1133 Å² buried · 26 hydrogen bonds · protein-protein
C–D · 1130 Å² buried · 26 hydrogen bonds · protein-protein
B–C · 354 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

3ELP · Structure of cystationine gamma lyase · the same entry in another collection · chain D against D, TM-score 1.00
P32929 · AlphaFold monomer V2.0 prediction for cystathionine gamma-lyase (P32929) · a predicted model of the same protein · chain C against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32929
Elsewhere: RCSB PDB 3ELP · PDBe 3ELP · UniProt P32929

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