UniProt P32929
Cystathionine gamma-lyase (P32929)
Cystathionine gamma-lyase (UniProt P32929), EC 4.4.1.1: 13 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P32929
- Protein
- Cystathionine gamma-lyase
- EC
- 4.4.1.1
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 1 record with a druggable one
Structures
14 records of P32929 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2NMP | Crystal structure of human Cystathionine gamma lyase | x-ray diffraction | A, B, C, D | — | — |
| 2NMP | Crystal structure of human cystathionine gamma lyase | x-ray diffraction | A, B, C, D | — | — |
| 3COG | Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 3COG | Crystal structure of human cystathionase (cystathionine gamma lyase) in complex with… | x-ray diffraction | A, B, C, D | — | — |
| 3ELP | Structure of cystationine gamma lyase | x-ray diffraction | B, A, C, D | — | — |
| 3ELP | Structure of cystationine gamma lyase | x-ray diffraction | B, A, C, D | — | — |
| 5EIG | Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5TSU | Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to… | x-ray diffraction | A, B, C, D, E, F, G, H | SO4, LPI | — |
| 5TSU | Active conformation for engineered human cystathionine gamma lyase (E59N, R119L, E339V) to… | x-ray diffraction | A, B, C, D, E, F, G, H | SO4, LPI | — |
| 5TT2 | Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to… | x-ray diffraction | C, D | SO4 | — |
| 6NBA | Crystal structure of human cystathionine gamma lyase with S-3- carboxpropyl-L-cysteine | x-ray diffraction | A, B, C, D | — | — |
| 6OVG | L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism | x-ray diffraction | A, B, C, D, E, F, G, H | SO4 | 20 (best 0.81) |
| 6OVG | L-methionine depletion with an engineered human enzyme disrupts prostate cancer metabolism | x-ray diffraction | A, B, C, D, E, F, G, H | SO4 | — |
| P32929 | AlphaFold monomer V2.0 prediction for cystathionine gamma-lyase (P32929) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6OVG chain A against the predicted model P32929: TM-score 1.00, RMSD 0.36 Å
- 6OVG chain A against the predicted model P32929: TM-score 1.00, RMSD 0.36 Å
- 5TSU chain C against the predicted model P32929: TM-score 1.00, RMSD 0.44 Å
- 5TSU chain C against the predicted model P32929: TM-score 1.00, RMSD 0.44 Å
- 6OVG chain G against the predicted model P32929: TM-score 1.00, RMSD 0.45 Å
- 6OVG chain G against the predicted model P32929: TM-score 1.00, RMSD 0.45 Å
- 5EIG chain A against the predicted model P32929: TM-score 1.00, RMSD 0.46 Å
- 6OVG chain F against the predicted model P32929: TM-score 1.00, RMSD 0.49 Å
- 6OVG chain F against the predicted model P32929: TM-score 1.00, RMSD 0.49 Å
- 5EIG chain F against the predicted model P32929: TM-score 1.00, RMSD 0.52 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.