MolNFT v1 · #6254 · protein
Mad crystal structure analysis of methyltetrahydrofolate: CORRINOID/IRON-sulfur protein methyltransferase (metr)
1F6Y · 5-methyltetrahydrofolate CORRINOID/IRON sulfur protein…: “Mad crystal structure analysis of methyltetrahydrofolate: CORRINOID/IRON-sulfur protein methyltransferase…”. X-ray diffraction, 3 pockets (best druggability 0.51). MolNFT v1…
- PDB
- 1F6Y
- Type
- protein
- Length
- 516 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5-methyltetrahydrofolate CORRINOID/IRON sulfur protein methyltransferase
- UniProt
- Q46389
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 5-methyltetrahydrofolate CORRINOID/IRON sulfur protein methyltransferase | protein | 258 | 51% helix, 15% strand | Q46389 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.51 | 0.75 | 31 | empty |
| 2 | 228 | 0.50 | 0.75 | 33 | empty |
| 3 | 89 | 0.35 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1471 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1F6Y · Mad crystal structure analysis of methyltetrahydrofolate: CORRINOID/IRON-sulfur protein… · the same entry in another collection · chain A against A, TM-score 1.00
- Q46389 · AlphaFold monomer V2.0 prediction for 5-METHYLTETRAHYDROFOLATE:CORRINOID/IRON-sulfur… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q46389
- Elsewhere: RCSB PDB 1F6Y · PDBe 1F6Y · UniProt Q46389
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