MolNFT v1 · #62511 · protein
Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1)
3EHS · Fusion protein of CRFR1 extracellular domain and mbp: “Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1)”. X-ray diffraction, 1 ligand (GLC), 1 pocket (best druggability…
- PDB
- 3EHS
- Type
- protein
- Length
- 457 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein of CRFR1 extracellular domain and mbp
- UniProt
- P0AEX9, P34998
- Ligands
- GLC
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein of CRFR1 extracellular domain and mbp | protein | 457 | 40% helix, 25% strand | P0AEX9, P34998 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 308 | 0.70 | 0.84 | 35 | GLC |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3EHS · Crystal structure of the extracellular domain of human corticotropin releasing factor… · the same entry in another collection · chain A against A, TM-score 1.00
- P34998 · AlphaFold monomer V2.0 prediction for corticotropin-releasing factor receptor 1 (P34998) · a predicted model of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt P34998
- Elsewhere: RCSB PDB 3EHS · PDBe 3EHS · UniProt P0AEX9 · UniProt P34998
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