MolNFT v1 · #62487 · protein + RNA
Crystal structure of an in vitro evolved tetracycline aptamer and artificial riboswitch
3EGZ · U1 small nuclear ribonucleoprotein a: “Crystal structure of an in vitro evolved tetracycline aptamer and artificial riboswitch”. X-ray diffraction, 2 ligands (CTC, MG), 4 pockets (best druggability 0.67). MolNFT v1 #62487 on…
- PDB
- 3EGZ
- Type
- protein + RNA
- Length
- 156 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U1 small nuclear ribonucleoprotein a; Tetracycline aptamer and artificial riboswitch
- UniProt
- P09012
- Ligands
- CTC, MG
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U1 small nuclear ribonucleoprotein a | protein | 91 | 33% helix, 26% strand | P09012 |
| B | Tetracycline aptamer and artificial riboswitch | rna | 65 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 666 | 0.67 | 0.77 | 38 | MG |
| 2 | 257 | 0.49 | 0.75 | 20 | MG |
| 3 | 154 | 0.40 | 0.74 | 18 | MG |
| 4 | 84 | 0.34 | 0.75 | 12 | CTC, MG |
Interfaces
1 interface between chains.
- A–B · 974 Ų buried · 29 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 3EGZ · Crystal structure of an in vitro evolved tetracycline aptamer and artificial riboswitch · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09012
- Elsewhere: RCSB PDB 3EGZ · PDBe 3EGZ · UniProt P09012
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.