MolNFT v1 · #62400 · protein
Crystal structure of human protein kinase CK2 regulatory subunit (CK2BETA; mutant 1-193)
3EED · Casein kinase II subunit beta: “Crystal structure of human protein kinase CK2 regulatory subunit (CK2BETA; mutant 1-193)”. X-ray diffraction, 2 ligands (ZN, SO4), 6 pockets (best druggability 0.56). MolNFT v1 #62400 on GenesisL1: 3D…
- PDB
- 3EED
- Type
- protein
- Length
- 366 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Casein kinase II subunit beta
- UniProt
- P67870
- Ligands
- ZN, SO4
- Pockets
- 6 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Casein kinase II subunit beta | protein | 183 | 43% helix, 10% strand | P67870 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.56 | 0.79 | 35 | empty |
| 2 | 86 | 0.40 | 0.78 | 15 | empty |
| 3 | 92 | 0.39 | 0.77 | 17 | empty |
| 4 | 50 | 0.31 | 0.76 | 12 | empty |
| 5 | 56 | 0.30 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1255 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3EED · Crystal structure of human protein kinase CK2 regulatory subunit (CK2beta; mutant 1-193) · the same entry in another collection · chain A against A, TM-score 1.00
- P67870 · AlphaFold monomer V2.0 prediction for casein kinase II subunit beta (P67870) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P67870
- Elsewhere: RCSB PDB 3EED · PDBe 3EED · UniProt P67870
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