MolNFT v1 · #6236 · protein
Crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the rat prolactin receptor
1F6F: “Crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the…”. X-ray diffraction, 7 pockets (best druggability 0.72). MolNFT v1 #6236 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1F6F
- Type
- protein
- Length
- 547 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Placental lactogen; Prolactin receptor
- UniProt
- P16038, P05710
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Placental lactogen | protein | 183 | 72% helix, 0% strand | P16038 |
| B | Prolactin receptor | protein | 195 | 2% helix, 49% strand | P05710 |
| C | Prolactin receptor | protein | 169 | 4% helix, 47% strand | P05710 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 952 | 0.72 | 0.76 | 82 | empty |
| 2 | 128 | 0.50 | 0.80 | 24 | empty |
| 3 | 182 | 0.45 | 0.74 | 25 | empty |
| 4 | 96 | 0.42 | 0.78 | 17 | empty |
| 5 | 65 | 0.38 | 0.80 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1035 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 817 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 576 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 1F6F · Crystal structure of the ternary complex between ovine placental lactogen and the… · the same entry in another collection · chain A against A, TM-score 1.00
- P16038 · AlphaFold monomer V2.0 prediction for chorionic somatomammotropin hormone (P16038) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P05710 · AlphaFold monomer V2.0 prediction for prolactin receptor (P05710) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16038
- Every structure of UniProt P05710
- Elsewhere: RCSB PDB 1F6F · PDBe 1F6F · UniProt P16038 · UniProt P05710
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.