Research workbench
Crystal structure of the ternary complex between ovine placental lactogen and the extracellular domain of the rat prolactin receptor
Analyse Crystal structure of the ternary complex between ovine placental lactogen and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1F6F
- Type
- protein
- Length
- 547 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Placental lactogen; Prolactin receptor
- UniProt
- P16038, P05710
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 26% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Placental lactogen | protein | 183 | 72% helix, 0% strand | P16038 |
| B | Prolactin receptor | protein | 195 | 2% helix, 49% strand | P05710 |
| C | Prolactin receptor | protein | 169 | 4% helix, 47% strand | P05710 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 952 | 0.72 | 0.76 | 82 | empty |
| 2 | 128 | 0.50 | 0.80 | 24 | empty |
| 3 | 182 | 0.45 | 0.74 | 25 | empty |
| 4 | 96 | 0.42 | 0.78 | 17 | empty |
| 5 | 65 | 0.38 | 0.80 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1035 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 817 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 576 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 1F6F · Crystal structure of the ternary complex between ovine placental lactogen and the… · the same entry in another collection · chain A against A, TM-score 1.00
- P16038 · AlphaFold monomer V2.0 prediction for chorionic somatomammotropin hormone (P16038) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P05710 · AlphaFold monomer V2.0 prediction for prolactin receptor (P05710) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16038
- Every structure of UniProt P05710
- Elsewhere: RCSB PDB 1F6F · PDBe 1F6F · UniProt P16038 · UniProt P05710
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