MolNFT v1 · #62287 · protein
Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone
3EB4 · Voltage-gated potassium channel subunit beta-2: “Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone”. X-ray diffraction, 2 ligands (NDP, PDN), 2 pockets (best druggability 0.72). MolNFT v1 #62287 on…
- PDB
- 3EB4
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel subunit beta-2
- UniProt
- P62483
- Ligands
- NDP, PDN
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated potassium channel subunit beta-2 | protein | 327 | 51% helix, 15% strand | P62483 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- PDN · 17,21-dihydroxypregna-1,4-diene-3,11,20-trione · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 409 | 0.72 | 0.82 | 55 | NDP, PDN |
| 2 | 91 | 0.34 | 0.74 | 21 | empty |
Compared structures
- 3EB4 · Voltage-dependent K+ channel beta subunit (I211R) in complex with cortisone · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Elsewhere: RCSB PDB 3EB4 · PDBe 3EB4 · UniProt P62483
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