MolNFT v1 · #62278 · protein
Voltage-dependent K+ channel beta subunit in complex with cortisone
3EAU · Voltage-gated potassium channel subunit beta-2: “Voltage-dependent K+ channel beta subunit in complex with cortisone”. X-ray diffraction, 2 ligands (PDN, NDP), 2 pockets (best druggability 0.72). MolNFT v1 #62278 on GenesisL1: 3D…
- PDB
- 3EAU
- Type
- protein
- Length
- 327 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel subunit beta-2
- UniProt
- P62483
- Ligands
- PDN, NDP
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-gated potassium channel subunit beta-2 | protein | 327 | 52% helix, 16% strand | P62483 |
Ligands and binding sites
- PDN · 17,21-dihydroxypregna-1,4-diene-3,11,20-trione · ligand · 2 copies · chains A
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 357 | 0.72 | 0.84 | 49 | NDP, PDN |
| 2 | 83 | 0.36 | 0.76 | 23 | empty |
Compared structures
- 3EAU · Voltage-dependent K+ channel beta subunit in complex with cortisone · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Elsewhere: RCSB PDB 3EAU · PDBe 3EAU · UniProt P62483
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