MolNFT v1 · #62263 · protein
Pwwp domain of human hepatoma-derived growth factor 2 (HDGF2)
3EAE · Hepatoma-derived growth factor-related protein 2: “Pwwp domain of human hepatoma-derived growth factor 2 (HDGF2)”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #62263 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3EAE
- Type
- protein
- Length
- 167 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hepatoma-derived growth factor-related protein 2
- UniProt
- Q7Z4V5
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hepatoma-derived growth factor-related protein 2 | protein | 92 | 23% helix, 23% strand | Q7Z4V5 |
| B | Hepatoma-derived growth factor-related protein 2 | protein | 75 | 28% helix, 28% strand | Q7Z4V5 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.37 | 0.79 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 428 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3EAE · PWWP domain of human hepatoma-derived growth factor 2 (HDGF2) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z4V5
- Elsewhere: RCSB PDB 3EAE · PDBe 3EAE · UniProt Q7Z4V5
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