MolNFT v1 · #62238 · protein
Crystal structure of yeast PRP8, residues 1827-2092
3E9P · Pre-mRNA-splicing factor 8: “Crystal structure of yeast PRP8, residues 1827-2092”. X-ray diffraction, 8 pockets (best druggability 0.68). MolNFT v1 #62238 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3E9P
- Type
- protein
- Length
- 510 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing factor 8
- UniProt
- P33334
- Pockets
- 8 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pre-mRNA-splicing factor 8 | protein | 255 | 44% helix, 18% strand | P33334 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 244 | 0.68 | 0.85 | 35 | empty |
| 2 | 400 | 0.66 | 0.79 | 49 | empty |
| 3 | 194 | 0.55 | 0.79 | 24 | empty |
| 4 | 72 | 0.51 | 0.84 | 13 | empty |
| 5 | 98 | 0.46 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1160 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3E9P · Crystal Structure of Yeast Prp8, Residues 1827-2092 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33334
- Elsewhere: RCSB PDB 3E9P · PDBe 3E9P · UniProt P33334
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