MolNFT v1 · #62130 · protein
MHC class I H-2DD heavy chain complexed with beta-2 microglobulin and a variant peptide, PI10, from the human immunodeficiency virus (bal) envelope glycoprotein 120
3E6H · H-2 class I histocompatibility antigen, D-D alpha chain: “MHC class I H-2DD heavy chain complexed with beta-2 microglobulin and a variant peptide, PI10, from the human…”. X-ray diffraction, 5 pockets (best druggability 0.66). MolNFT…
- PDB
- 3E6H
- Type
- protein
- Length
- 383 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H-2 class I histocompatibility antigen, D-D alpha chain; Putative uncharacterized…
- UniProt
- P01900, Q91XJ8, A4L8F7
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | H-2 class I histocompatibility antigen, D-D alpha chain | protein | 274 | 28% helix, 39% strand | P01900 |
| B | Putative uncharacterized protein | protein | 99 | 0% helix, 52% strand | Q91XJ8 |
| P | Envelope glycoprotein 10-residue peptide | protein | 10 | 0% helix, 0% strand | A4L8F7 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.66 | 0.79 | 53 | empty |
| 2 | 170 | 0.53 | 0.79 | 25 | empty |
| 3 | 54 | 0.33 | 0.78 | 14 | empty |
| 4 | 87 | 0.33 | 0.74 | 18 | empty |
| 5 | 54 | 0.29 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1422 Ų buried · 16 hydrogen bonds · protein-protein
- A–P · 881 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 3E6H · MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide… · the same entry in another collection · chain A against A, TM-score 1.00
- P01900 · AlphaFold monomer V2.0 prediction for H-2 class I histocompatibility antigen, D-D alpha… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01900
- Every structure of UniProt Q91XJ8
- Every structure of UniProt A4L8F7
- Elsewhere: RCSB PDB 3E6H · PDBe 3E6H · UniProt P01900 · UniProt Q91XJ8 · UniProt A4L8F7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.