MolNFT v1 · #61967 · protein
Crystal structure of kluyveromyces lactis GAL80P in complex with the acidic activation domain of GAL4P
3E1K · GALACTOSE/LACTOSE metabolism regulatory protein GAL80: “Crystal structure of kluyveromyces lactis GAL80P in complex with the acidic activation domain of GAL4P”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1…
- PDB
- 3E1K
- Type
- protein
- Length
- 3,258 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GALACTOSE/LACTOSE metabolism regulatory protein GAL80; Lactose regulatory protein LAC9
- UniProt
- Q06433, P08657
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 395 | 31% helix, 27% strand | Q06433 |
| B, D, F, H, J, L, N, P | Lactose regulatory protein LAC9 | protein | 14 | 50% helix, 0% strand | P08657 |
| C, E, G, I, K, M, O | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 393 | 31% helix, 28% strand | Q06433 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 727 | 0.75 | 0.80 | 80 | empty |
| 2 | 734 | 0.75 | 0.80 | 89 | empty |
| 3 | 592 | 0.74 | 0.81 | 66 | empty |
| 4 | 708 | 0.74 | 0.80 | 80 | empty |
| 5 | 629 | 0.74 | 0.80 | 71 | empty |
Interfaces
19 interfaces between chains.
- E–G · 1973 Ų buried · 34 hydrogen bonds · protein-protein
- A–C · 1968 Ų buried · 32 hydrogen bonds · protein-protein
- I–K · 1954 Ų buried · 26 hydrogen bonds · protein-protein
- M–O · 1921 Ų buried · 27 hydrogen bonds · protein-protein
- K–O · 851 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3E1K · Crystal structure of Kluyveromyces lactis Gal80p in complex with the acidic activation… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06433
- Every structure of UniProt P08657
- Elsewhere: RCSB PDB 3E1K · PDBe 3E1K · UniProt Q06433 · UniProt P08657
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