Research workbench
Crystal structure of kluyveromyces lactis GAL80P in complex with the acidic activation domain of GAL4P
Analyse Crystal structure of kluyveromyces lactis GAL80P in complex with the acidic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3E1K
- Type
- protein
- Length
- 3,258 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GALACTOSE/LACTOSE metabolism regulatory protein GAL80; Lactose regulatory protein LAC9
- UniProt
- Q06433, P08657
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 395 | 31% helix, 27% strand | Q06433 |
| B, D, F, H, J, L, N, P | Lactose regulatory protein LAC9 | protein | 14 | 50% helix, 0% strand | P08657 |
| C, E, G, I, K, M, O | GALACTOSE/LACTOSE metabolism regulatory protein GAL80 | protein | 393 | 31% helix, 28% strand | Q06433 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 727 | 0.75 | 0.80 | 80 | empty |
| 2 | 734 | 0.75 | 0.80 | 89 | empty |
| 3 | 592 | 0.74 | 0.81 | 66 | empty |
| 4 | 708 | 0.74 | 0.80 | 80 | empty |
| 5 | 629 | 0.74 | 0.80 | 71 | empty |
Interfaces
19 interfaces between chains.
- E–G · 1973 Ų buried · 34 hydrogen bonds · protein-protein
- A–C · 1968 Ų buried · 32 hydrogen bonds · protein-protein
- I–K · 1954 Ų buried · 26 hydrogen bonds · protein-protein
- M–O · 1921 Ų buried · 27 hydrogen bonds · protein-protein
- K–O · 851 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3E1K · Crystal structure of Kluyveromyces lactis Gal80p in complex with the acidic activation… · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06433
- Every structure of UniProt P08657
- Elsewhere: RCSB PDB 3E1K · PDBe 3E1K · UniProt Q06433 · UniProt P08657
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