MolNFT v1 · #61798 · protein
Structure of human ece-1 complexed with phosphoramidon
3DWB · Endothelin-converting enzyme 1: “Structure of human ece-1 complexed with phosphoramidon”. X-ray diffraction, 3 ligands (5HD, RDF, ZN), 10 pockets (best druggability 0.71). MolNFT v1 #61798 on GenesisL1: 3D structure, binding sites…
- PDB
- 3DWB
- Type
- protein
- Length
- 660 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endothelin-converting enzyme 1
- EC
- 3.4.24.71
- UniProt
- P42892
- Ligands
- 5HD, RDF, ZN
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 57% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endothelin-converting enzyme 1 (EC 3.4.24.71) | protein | 660 | 57% helix, 8% strand | P42892 |
Ligands and binding sites
- 5HD · 5-(2-hydroxyethyl)nonane-1,9-diol · ligand · chains A
- RDF · N-alpha-L-rhamnopyranosyloxy(hydroxyphosphinyl)-L-leucyl-L-tryptophan · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 389 | 0.71 | 0.82 | 45 | RDF |
| 2 | 729 | 0.70 | 0.77 | 59 | 5HD |
| 3 | 235 | 0.59 | 0.79 | 25 | empty |
| 4 | 233 | 0.56 | 0.78 | 36 | empty |
| 5 | 155 | 0.51 | 0.79 | 29 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42892
- Elsewhere: RCSB PDB 3DWB · PDBe 3DWB · UniProt P42892
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