MolNFT v1 · #61775 · protein
Crystal structure of CA2+/CAM-CAV2.1 iq domain complex
3DVM · Calmodulin: “Crystal structure of CA2+/CAM-CAV2.1 iq domain complex”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.52). MolNFT v1 #61775 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3DVM
- Type
- protein
- Length
- 162 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Voltage-dependent P/Q-type calcium channel subunit alpha- 1A
- UniProt
- P62158, P27884
- Ligands
- CA
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 140 | 60% helix, 6% strand | P62158 |
| B | Voltage-dependent P/Q-type calcium channel subunit alpha- 1A | protein | 22 | 77% helix, 0% strand | P27884 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 135 | 0.52 | 0.80 | 17 | empty |
| 2 | 75 | 0.38 | 0.77 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1355 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3DVM · Crystal Structure of Ca2+/CaM-CaV2.1 IQ domain complex · the same entry in another collection · chain A against A, TM-score 1.00
- P27884 · AlphaFold monomer V2.0 prediction for voltage-dependent P/Q-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt P27884
- Elsewhere: RCSB PDB 3DVM · PDBe 3DVM · UniProt P62158 · UniProt P27884
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