MolNFT v1 · #6112 · protein
NMR structure of the heterodimeric complex between cad domains of cad and icad
1F2R · Caspase-activated DNase: “NMR structure of the heterodimeric complex between cad domains of cad and icad”. Solution nmr, 1 pocket (best druggability 0.31). MolNFT v1 #6112 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1F2R
- Type
- protein
- Length
- 187 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase-activated DNase; Inhibitor of caspase-activated DNase
- UniProt
- O54788, O54786
- Pockets
- 1 · best druggability 0.31
Structure
solution nmr · 2 distinct chains · 14% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Caspase-activated DNase | protein | 87 | 14% helix, 28% strand | O54788 |
| I | Inhibitor of caspase-activated DNase | protein | 100 | 15% helix, 26% strand | O54786 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.31 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- C–I · 596 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1F2R · NMR structure of the heterodimeric complex between cad domains of cad and icad · the same entry in another collection · chain C against C, TM-score 1.00
- O54788 · AlphaFold monomer V2.0 prediction for DNA fragmentation factor subunit beta (O54788) · a predicted model of the same protein · chain C against A, TM-score 0.75
- O54786 · AlphaFold monomer V2.0 prediction for DNA fragmentation factor subunit alpha (O54786) · a predicted model of the same protein · chain I against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O54788
- Every structure of UniProt O54786
- Elsewhere: RCSB PDB 1F2R · PDBe 1F2R · UniProt O54788 · UniProt O54786
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