Research workbench
NMR structure of the heterodimeric complex between cad domains of cad and icad
Analyse NMR structure of the heterodimeric complex between cad domains of cad and icad in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1F2R
- Type
- protein
- Length
- 187 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Caspase-activated DNase; Inhibitor of caspase-activated DNase
- UniProt
- O54788, O54786
- Pockets
- 1 · best druggability 0.31
Structure
solution nmr · 2 distinct chains · 14% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Caspase-activated DNase | protein | 87 | 14% helix, 28% strand | O54788 |
| I | Inhibitor of caspase-activated DNase | protein | 100 | 15% helix, 26% strand | O54786 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.31 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- C–I · 596 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1F2R · NMR structure of the heterodimeric complex between cad domains of cad and icad · the same entry in another collection · chain C against C, TM-score 1.00
- O54788 · AlphaFold monomer V2.0 prediction for DNA fragmentation factor subunit beta (O54788) · a predicted model of the same protein · chain C against A, TM-score 0.75
- O54786 · AlphaFold monomer V2.0 prediction for DNA fragmentation factor subunit alpha (O54786) · a predicted model of the same protein · chain I against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O54788
- Every structure of UniProt O54786
- Elsewhere: RCSB PDB 1F2R · PDBe 1F2R · UniProt O54788 · UniProt O54786
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