MolNFT v1 · #60717 · protein
Human P53 core domain with hot spot mutation R249S (II)
3D05 · Cellular tumor antigen P53: “Human P53 core domain with hot spot mutation R249S (II)”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.36). MolNFT v1 #60717 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3D05
- Type
- protein
- Length
- 183 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cellular tumor antigen P53
- UniProt
- P04637
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.36
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cellular tumor antigen P53 | protein | 183 | 11% helix, 36% strand | P04637 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.36 | 0.75 | 20 | empty |
| 2 | 60 | 0.34 | 0.77 | 19 | empty |
Compared structures
- 3D05 · Human p53 core domain with hot spot mutation R249S (II) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04637
- Elsewhere: RCSB PDB 3D05 · PDBe 3D05 · UniProt P04637
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