MolNFT v1 · #60568 · protein

High resolution structure of a stable plasminogen activator inhibitor type-1 in its protease cleaved form

3CVM · Plasminogen activator inhibitor 1: “High resolution structure of a stable plasminogen activator inhibitor type-1 in its protease cleaved form”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #60568 on GenesisL1: 3D…

PDB: 3CVM
Type: protein
Length: 754 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasminogen activator inhibitor 1
UniProt: P05121
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Plasminogen activator inhibitor 1	protein	377	30% helix, 38% strand	P05121

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	585	0.68	0.77	67	empty
2	68	0.62	0.91	23	empty
3	365	0.62	0.78	54	empty
4	58	0.40	0.81	20	empty

Interfaces

1 interface between chains.

A–B · 1177 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

3CVM · High resolution structure of a stable Plasminogen activator inhibitor type-1 in its… · the same entry in another collection · chain A against A, TM-score 1.00
P05121 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 1 (P05121) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05121
Elsewhere: RCSB PDB 3CVM · PDBe 3CVM · UniProt P05121

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