MolNFT v1 · #60522 · protein

Human complement component 5

3CU7 · Complement C5: “Human complement component 5”. X-ray diffraction, 2 ligands (NAG, CD), 20 pockets (best druggability 0.84). MolNFT v1 #60522 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CU7
Type: protein
Length: 3,106 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement C5
UniProt: P01031
Ligands: NAG, CD
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Complement C5	protein	1625	17% helix, 31% strand	P01031
B	Complement C5	protein	1481	17% helix, 32% strand	P01031

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B
CD · Cadmium ion · metal · 9 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	886	0.84	0.86	77	CD
2	829	0.84	0.86	94	CD
3	840	0.83	0.86	95	CD
4	977	0.81	0.83	99	empty
5	967	0.81	0.82	99	empty

Interfaces

1 interface between chains.

A–B · 1289 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 25 disulfide, 4 glycan (disulfide, N-glycosylation).

Compared structures

3CU7 · Human Complement Component 5 · the same entry in another collection · chain A against A, TM-score 1.00
P01031 · AlphaFold monomer V2.0 prediction for complement C5 (P01031) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01031
Elsewhere: RCSB PDB 3CU7 · PDBe 3CU7 · UniProt P01031

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