MolNFT v1 · #60515 · protein
Structure of human cytosolic X-prolyl aminopeptidase
3CTZ · Xaa-pro aminopeptidase 1: “Structure of human cytosolic X-prolyl aminopeptidase”. X-ray diffraction, 3 ligands (MN, CA, NA), 5 pockets (best druggability 0.67). MolNFT v1 #60515 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3CTZ
- Type
- protein
- Length
- 617 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Xaa-pro aminopeptidase 1
- EC
- 3.4.11.9
- UniProt
- Q9NQW7
- Ligands
- MN, CA, NA
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Xaa-pro aminopeptidase 1 (EC 3.4.11.9) | protein | 617 | 40% helix, 20% strand | Q9NQW7 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · 2 copies · chains A
- CA · Calcium ion · metal · chains A
- NA · Sodium ion · metal · chains A
- P6G · Hexaethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 641 | 0.67 | 0.77 | 62 | MN, NA, P6G |
| 2 | 233 | 0.55 | 0.77 | 29 | empty |
| 3 | 196 | 0.43 | 0.73 | 31 | empty |
| 4 | 52 | 0.35 | 0.78 | 16 | empty |
| 5 | 60 | 0.31 | 0.75 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NQW7
- Elsewhere: RCSB PDB 3CTZ · PDBe 3CTZ · UniProt Q9NQW7
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