MolNFT v1 · #60322 · protein + DNA

Crystal structure of FOXO1 dbd bound to DBE2 DNA

3CO7 · DNA (5'- D(*DTP*DCP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DAP*DTP*…: “Crystal structure of FOXO1 dbd bound to DBE2 DNA”. X-ray diffraction, 8 pockets (best druggability 0.38). MolNFT v1 #60322 on GenesisL1: 3D structure, binding sites and…

PDB: 3CO7
Type: protein + DNA
Length: 238 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'- D(*DTP*DCP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DAP*DTP*DTP*DTP*DTP*DG)- 3'); DNA…
UniProt: Q12778
Pockets: 8 · best druggability 0.38

Structure

x-ray diffraction · 3 distinct chains · 40% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	DNA (5'- D(DTPDCPDTPDTPDGPDTPDTPDTPDAPDCPDAPDTPDTPDTPDTPDG)- 3')	dna	16	—	—
B, E	DNA (5'- D(DCPDAPDAPDAPDAPDTPDGPDTPDAPDAPDAPDCPDAPDAPDGPDA)- 3')	dna	16	—	—
C, F	Forkhead box protein O1	protein	87	40% helix, 14% strand	Q12778

Pockets

8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.38	0.78	14	empty
2	87	0.38	0.77	15	empty
3	140	0.38	0.74	16	empty
4	110	0.37	0.74	19	empty
5	103	0.34	0.74	16	empty

Interfaces

10 interfaces between chains.

A–B · 717 Å² buried · 55 hydrogen bonds · nucleic-nucleic
D–E · 713 Å² buried · 56 hydrogen bonds · nucleic-nucleic
A–C · 488 Å² buried · 8 hydrogen bonds · protein-nucleic
D–F · 488 Å² buried · 9 hydrogen bonds · protein-nucleic
B–C · 418 Å² buried · 8 hydrogen bonds · protein-nucleic

Compared structures

3CO7 · Crystal Structure of FoxO1 DBD Bound to DBE2 DNA · the same entry in another collection · chain F against F, TM-score 1.00
Q12778 · AlphaFold monomer V2.0 prediction for forkhead box protein O1 (Q12778) · a predicted model of the same protein · chain F against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12778
Elsewhere: RCSB PDB 3CO7 · PDBe 3CO7 · UniProt Q12778

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.