UniProt Q12778
Forkhead box protein O1 (Q12778)
Forkhead box protein O1 (UniProt Q12778): 15 experimental structures and 1 predicted model on GenesisL1, 11 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q12778
- Protein
- Forkhead box protein O1
- Experimental structures
- 15
- Predicted models
- 1
- Pockets
- 11 · 1 record with a druggable one
Structures
16 records of Q12778 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3CO6 | Crystal Structure of FoxO1 DBD Bound to DBE1 DNA | x-ray diffraction | C | — | — |
| 3CO6 | Crystal structure of FOXO1 dbd bound to DBE1 DNA | x-ray diffraction | C | — | — |
| 3CO7 | Crystal Structure of FoxO1 DBD Bound to DBE2 DNA | x-ray diffraction | C, F | — | — |
| 3CO7 | Crystal structure of FOXO1 dbd bound to DBE2 DNA | x-ray diffraction | C, F | — | — |
| 3COA | Crystal Structure of FoxO1 DBD Bound to IRE DNA | x-ray diffraction | C, F | — | — |
| 3COA | Crystal structure of FOXO1 dbd bound to ire DNA | x-ray diffraction | C, F | — | — |
| 4LG0 | Structure of a ternary FOXO1-ETS1 DNA complex | x-ray diffraction | A | — | — |
| 4LG0 | Structure of a ternary FOXO1-ETS1 DNA complex | x-ray diffraction | A | — | — |
| 5DUI | Identification of a new FoxO1 binding site that precludes CREB binding at the glucose-6-phosphatase… | x-ray diffraction | A, B | — | — |
| 5DUI | Identification of a new FOXO1 binding site that precludes creb binding at the glucose-6-phosphatase… | x-ray diffraction | A, B | — | — |
| 6LBI | Crystal structure of FOXO1-dbd homodimer bound to a palindromic DNA sequence | x-ray diffraction | C, D, G, H, K, L | — | — |
| 6QVW | Solution structure of the free FOXO1 DNA binding domain | solution nmr | A | — | — |
| 6QVW | Solution structure of the free FOXO1 DNA binding domain | solution nmr | A | — | — |
| 6QZR | 14-3-3 sigma in complex with FOXO1 pT24 peptide | x-ray diffraction | R, J, M, N, O, P, T, U | — | 11 (best 0.58) |
| 6QZR | 14-3-3 sigma in complex with FOXO1 PT24 peptide | x-ray diffraction | R, J, M, N, O, P, T, U | — | — |
| Q12778 | AlphaFold monomer V2.0 prediction for forkhead box protein O1 (Q12778) | predicted | A | — | — |
Experiment against prediction
- 6LBI chain H against the predicted model Q12778: TM-score 0.96, RMSD 0.63 Å
- 6LBI chain G against the predicted model Q12778: TM-score 0.94, RMSD 0.93 Å
- 6LBI chain L against the predicted model Q12778: TM-score 0.94, RMSD 1.04 Å
- 3COA chain C against the predicted model Q12778: TM-score 0.94, RMSD 1.14 Å
- 3COA chain C against the predicted model Q12778: TM-score 0.94, RMSD 1.14 Å
- 6LBI chain C against the predicted model Q12778: TM-score 0.93, RMSD 1.15 Å
- 6LBI chain K against the predicted model Q12778: TM-score 0.93, RMSD 1.41 Å
- 3COA chain F against the predicted model Q12778: TM-score 0.93, RMSD 1.38 Å
- 3COA chain F against the predicted model Q12778: TM-score 0.93, RMSD 1.38 Å
- 3CO7 chain F against the predicted model Q12778: TM-score 0.92, RMSD 1.38 Å
Elsewhere
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