MolNFT v1 · #60206 · protein
Crystal structure of sterile 20-like kinase 3 (MST3, STK24)
3CKW · SERINE/THREONINE-protein kinase 24: “Crystal structure of sterile 20-like kinase 3 (MST3, STK24)”. X-ray diffraction, 1 ligand (HG), 2 pockets (best druggability 0.55). MolNFT v1 #60206 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3CKW
- Type
- protein
- Length
- 255 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase 24
- EC
- 2.7.11.1
- UniProt
- Q9Y6E0
- Ligands
- HG
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase 24 (EC 2.7.11.1) | protein | 255 | 44% helix, 17% strand | Q9Y6E0 |
Ligands and binding sites
- HG · Mercury (II) ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 191 | 0.55 | 0.79 | 28 | empty |
| 2 | 113 | 0.53 | 0.82 | 20 | HG |
Compared structures
- 3CKW · Crystal structure of sterile 20-like kinase 3 (MST3, STK24) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y6E0 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 24 (Q9Y6E0) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y6E0
- Elsewhere: RCSB PDB 3CKW · PDBe 3CKW · UniProt Q9Y6E0
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