MolNFT v1 · #60168 · protein
Ribosomal protein L11 methyltransferase (prma) in complex with ribosomal protein L11 (K39A) and inhibitor sinefungin.
3CJR: “Ribosomal protein L11 methyltransferase (prma) in complex with ribosomal protein L11 (K39A) and inhibitor…”. X-ray diffraction, 1 ligand (SFG), 2 pockets (best druggability 0.71). MolNFT v1 #60168 on GenesisL1: 3D structure, binding…
- PDB
- 3CJR
- Type
- protein
- Length
- 367 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal protein L11 methyltransferase; 50S ribosomal protein L11
- EC
- 2.1.1.-
- UniProt
- Q84BQ9, P36238
- Ligands
- SFG
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal protein L11 methyltransferase (EC 2.1.1.-) | protein | 249 | 34% helix, 32% strand | Q84BQ9 |
| B | 50S ribosomal protein L11 | protein | 118 | 35% helix, 20% strand | P36238 |
Ligands and binding sites
- SFG · Sinefungin · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 632 | 0.71 | 0.79 | 60 | SFG |
| 2 | 211 | 0.57 | 0.79 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1228 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3CJR · Ribosomal protein L11 methyltransferase (PrmA) in complex with ribosomal protein L11… · the same entry in another collection · chain A against A, TM-score 1.00
- P36238 · AlphaFold monomer V2.0 prediction for 50S ribosomal protein L11 (P36238) · a predicted model of the same protein · chain B against A, TM-score 0.90
- Q84BQ9 · AlphaFold monomer V2.0 prediction for ribosomal protein L11 methyltransferase (Q84BQ9) · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q84BQ9
- Every structure of UniProt P36238
- Elsewhere: RCSB PDB 3CJR · PDBe 3CJR · UniProt Q84BQ9 · UniProt P36238
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.