MolNFT v1 · #60096 · protein
Solution structure of human secretory IGA1
3CHN · Immunoglobulin kappa light chain: “Solution structure of human secretory IGA1”. Solution scattering, 11 pockets (best druggability 0.60). MolNFT v1 #60096 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3CHN
- Type
- protein
- Length
- 3,447 residues
- Chains
- 10
- Method
- solution scattering
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin kappa light chain; Ig alpha-1 chain C region; Secretory component
- UniProt
- P01876, P01833
- Pockets
- 11 · best druggability 0.60
Structure
solution scattering · 4 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, M, N, O | Immunoglobulin kappa light chain | protein | 214 | 0% helix, 0% strand | — |
| A, B, D, C | Ig alpha-1 chain C region | protein | 475 | 0% helix, 0% strand | P01876 |
| J | Secretory component | protein | 106 | 0% helix, 0% strand | P01833 |
| S | Secretory component | protein | 585 | 0% helix, 0% strand | P01833 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.60 | 0.73 | 93 | empty |
| 2 | 327 | 0.59 | 0.75 | 79 | empty |
| 3 | 172 | 0.46 | 0.73 | 42 | empty |
| 4 | 164 | 0.45 | 0.73 | 37 | empty |
| 5 | 113 | 0.39 | 0.73 | 29 | empty |
Interfaces
13 interfaces between chains.
- B–S · 976 Ų buried · 0 hydrogen bonds · protein-protein
- D–S · 970 Ų buried · 0 hydrogen bonds · protein-protein
- J–S · 762 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 221 Ų buried · 0 hydrogen bonds · protein-protein
- D–C · 204 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3CHN · Solution structure of human secretory IgA1 · the same entry in another collection · chain S against S, TM-score 1.00
- P01833 · AlphaFold monomer V2.0 prediction for polymeric immunoglobulin receptor (P01833) · a predicted model of the same protein · chain J against A, TM-score 0.95
- P01876 · AlphaFold monomer V2.0 prediction for immunoglobulin heavy constant alpha 1 (P01876) · a predicted model of the same protein · chain A against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01876
- Every structure of UniProt P01833
- Elsewhere: RCSB PDB 3CHN · PDBe 3CHN · UniProt P01876 · UniProt P01833
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