MolNFT v1 · #60042 · protein
Crystal structure of signal receiver domain of modulated diguanylate cyclase from desulfovibrio desulfuricans G20, an example of alternate folding
3CG0 · Response regulator receiver modulated diguanylate cyclase…: “Crystal structure of signal receiver domain of modulated diguanylate cyclase from desulfovibrio desulfuricans…”. X-ray diffraction, 7 pockets (best druggability 0.75).…
- PDB
- 3CG0
- Type
- protein
- Length
- 503 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor
- UniProt
- Q311G8
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor | protein | 126 | 48% helix, 21% strand | Q311G8 |
| B | Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor | protein | 125 | 46% helix, 22% strand | Q311G8 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 835 | 0.75 | 0.79 | 73 | empty |
| 2 | 219 | 0.69 | 0.86 | 36 | empty |
| 3 | 128 | 0.50 | 0.80 | 28 | empty |
| 4 | 76 | 0.47 | 0.82 | 21 | empty |
| 5 | 54 | 0.32 | 0.76 | 12 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2857 Ų buried · 43 hydrogen bonds · protein-protein
- C–D · 557 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 211 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 168 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 166 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3CG0 · Crystal structure of signal receiver domain of modulated diguanylate cyclase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q311G8
- Elsewhere: RCSB PDB 3CG0 · PDBe 3CG0 · UniProt Q311G8
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