Research workbench
Crystal structure of signal receiver domain of modulated diguanylate cyclase from desulfovibrio desulfuricans G20, an example of alternate folding
Analyse Crystal structure of signal receiver domain of modulated diguanylate cyclase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3CG0
- Type
- protein
- Length
- 503 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor
- UniProt
- Q311G8
- Pockets
- 7 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor | protein | 126 | 48% helix, 21% strand | Q311G8 |
| B | Response regulator receiver modulated diguanylate cyclase with PAS/PAC sensor | protein | 125 | 46% helix, 22% strand | Q311G8 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 835 | 0.75 | 0.79 | 73 | empty |
| 2 | 219 | 0.69 | 0.86 | 36 | empty |
| 3 | 128 | 0.50 | 0.80 | 28 | empty |
| 4 | 76 | 0.47 | 0.82 | 21 | empty |
| 5 | 54 | 0.32 | 0.76 | 12 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2857 Ų buried · 43 hydrogen bonds · protein-protein
- C–D · 557 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 211 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 168 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 166 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3CG0 · Crystal structure of signal receiver domain of modulated diguanylate cyclase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q311G8
- Elsewhere: RCSB PDB 3CG0 · PDBe 3CG0 · UniProt Q311G8
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