MolNFT v1 · #59911 · protein

Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B)

3CC6: “Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B)”. X-ray diffraction, 1 ligand (MG), 2 pockets (best druggability 0.68). MolNFT v1 #59911 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3CC6
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein tyrosine kinase 2 beta
EC: 2.7.10.2
UniProt: Q14289
Ligands: MG
Pockets: 2 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein tyrosine kinase 2 beta (EC 2.7.10.2)	protein	269	45% helix, 17% strand	Q14289

Ligands and binding sites

MG · Magnesium ion · metal · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	457	0.68	0.79	47	empty
2	51	0.30	0.76	19	empty

Compared structures

3CC6 · Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B) · the same entry in another collection · chain A against A, TM-score 1.00
Q14289 · AlphaFold monomer V2.0 prediction for protein-tyrosine kinase 2-beta (Q14289) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14289
Elsewhere: RCSB PDB 3CC6 · PDBe 3CC6 · UniProt Q14289

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