MolNFT v1 · #59905 · protein
The DVL2 PDZ domain in complex with the N2 inhibitory peptide
3CBZ · Dishevelled-2: “The DVL2 PDZ domain in complex with the N2 inhibitory peptide”. X-ray diffraction, 1 ligand (PO4), 1 pocket (best druggability 0.31). MolNFT v1 #59905 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3CBZ
- Type
- protein
- Length
- 104 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dishevelled-2
- UniProt
- O14641
- Ligands
- PO4
- Pockets
- 1 · best druggability 0.31
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dishevelled-2 | protein | 104 | 20% helix, 31% strand | O14641 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.31 | 0.75 | 11 | empty |
Compared structures
- 3CBZ · The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide · the same entry in another collection · chain A against A, TM-score 1.00
- O14641 · AlphaFold monomer V2.0 prediction for segment polarity protein dishevelled homolog dvl-2… · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14641
- Elsewhere: RCSB PDB 3CBZ · PDBe 3CBZ · UniProt O14641
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