MolNFT v1 · #59766 · protein

Hemopexin-like domain of matrix metalloproteinase 14

3C7X · Matrix metalloproteinase-14: “Hemopexin-like domain of matrix metalloproteinase 14”. X-ray diffraction, 2 ligands (NA, CL), 1 pocket (best druggability 0.39). MolNFT v1 #59766 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 3C7X
Type: protein
Length: 196 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Matrix metalloproteinase-14
EC: 3.4.24.80
UniProt: P50281
Ligands: NA, CL
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Matrix metalloproteinase-14 (EC 3.4.24.80)	protein	196	9% helix, 42% strand	P50281

Ligands and binding sites

NA · Sodium ion · metal · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.39	0.74	20	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3C7X · Hemopexin-like domain of matrix metalloproteinase 14 · the same entry in another collection · chain A against A, TM-score 1.00
P50281 · AlphaFold monomer V2.0 prediction for matrix metalloproteinase-14 (P50281) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50281
Elsewhere: RCSB PDB 3C7X · PDBe 3C7X · UniProt P50281

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