MolNFT v1 · #59689 · protein

Polo-like kinase 1 polo box domain in complex with pphspt peptide

3C5L · SERINE/THREONINE-protein kinase PLK1: “Polo-like kinase 1 polo box domain in complex with pphspt peptide”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #59689 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 3C5L
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase PLK1; Peptide
EC: 2.7.11.21
UniProt: P53350
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 29% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21)	protein	217	30% helix, 30% strand	P53350
B	Peptide	protein	5	0% helix, 20% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.43	0.82	17	empty

Interfaces

1 interface between chains.

A–B · 439 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

3C5L · Polo-like kinase 1 Polo box domain in complex with PPHSpT peptide · the same entry in another collection · chain A against A, TM-score 1.00
P53350 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK1 (P53350) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53350
Elsewhere: RCSB PDB 3C5L · PDBe 3C5L · UniProt P53350

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