MolNFT v1 · #59666 · protein
Structure of class II fructose-biphosphate aldolase from helicobacter pylori
3C4U · Fructose-bisphosphate aldolase: “Structure of class II fructose-biphosphate aldolase from helicobacter pylori”. X-ray diffraction, 2 ligands (NA, ZN), 3 pockets (best druggability 0.55). MolNFT v1 #59666 on GenesisL1: 3D structure…
- PDB
- 3C4U
- Type
- protein
- Length
- 584 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-bisphosphate aldolase
- EC
- 4.1.2.13
- UniProt
- P56109
- Ligands
- NA, ZN
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fructose-bisphosphate aldolase (EC 4.1.2.13) | protein | 292 | 54% helix, 15% strand | P56109 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 280 | 0.55 | 0.77 | 38 | empty |
| 2 | 258 | 0.52 | 0.76 | 31 | empty |
| 3 | 62 | 0.34 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1890 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 3C4U · Structure of class II fructose-biphosphate aldolase from helicobacter pylori · the same entry in another collection · chain A against A, TM-score 1.00
- P56109 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase (P56109) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56109
- Elsewhere: RCSB PDB 3C4U · PDBe 3C4U · UniProt P56109
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