MolNFT v1 · #59607 · protein

TRNA-guanine transglycosylase (tgt) in complex with 6-amino-2-methyl- 1,7-dihydro-IMIDAZO[4,5-G]QUINAZOLIN-8-one

3C2Y · Queuine tRNA-ribosyltransferase: “TRNA-guanine transglycosylase (tgt) in complex with 6-amino-2-methyl…”. X-ray diffraction, 2 ligands (S60, ZN), 2 pockets (best druggability 0.53). MolNFT v1 #59607 on GenesisL1: 3D structure…

PDB: 3C2Y
Type: protein
Length: 361 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: S60, ZN
Pockets: 2 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	361	45% helix, 19% strand	P28720

Ligands and binding sites

S60 · 6-amino-2-methyl-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one · ligand · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · 5 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.53	0.82	24	S60
2	55	0.40	0.81	17	empty

Compared structures

3C2Y · tRNA-Guanine Transglycosylase (TGT) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 3C2Y · PDBe 3C2Y · UniProt P28720

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.