MolNFT v1 · #59486 · protein
Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal localization
3BZI · SERINE/THREONINE-protein kinase PLK1: “Molecular and structural basis of polo-like kinase 1 substrate recognition: implications in centrosomal…”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #59486 on GenesisL1…
- PDB
- 3BZI
- Type
- protein
- Length
- 230 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase PLK1; 9 mer peptide from M-phase inducer phosphatase 3
- EC
- 2.7.11.21
- UniProt
- P53350, P30307
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase PLK1 (EC 2.7.11.21) | protein | 223 | 30% helix, 30% strand | P53350 |
| E | 9 mer peptide from M-phase inducer phosphatase 3 | protein | 7 | 0% helix, 43% strand | P30307 |
Ligands and binding sites
- FMT · Formic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.38 | 0.79 | 16 | FMT |
| 2 | 62 | 0.36 | 0.78 | 19 | empty |
Interfaces
1 interface between chains.
- A–E · 556 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3BZI · Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications… · the same entry in another collection · chain A against A, TM-score 1.00
- P53350 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK1 (P53350) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P30307 · AlphaFold monomer V2.0 prediction for M-phase inducer phosphatase 3 (P30307) · a predicted model of the same protein · chain E against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53350
- Every structure of UniProt P30307
- Elsewhere: RCSB PDB 3BZI · PDBe 3BZI · UniProt P53350 · UniProt P30307
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.