MolNFT v1 · #59424 · protein
Crystal structure of the R-type calcium channel (CAV2.3) iq domain and CA2+CALMODULIN complex
3BXL: “Crystal structure of the R-type calcium channel (CAV2.3) iq domain and CA2+CALMODULIN complex”. X-ray diffraction, 2 ligands (CA, SO4), 1 pocket (best druggability 0.51). MolNFT v1 #59424 on GenesisL1: 3D structure, binding sites…
- PDB
- 3BXL
- Type
- protein
- Length
- 162 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Voltage-dependent R-type calcium channel subunit alpha-1E peptide
- UniProt
- P62161, Q07652
- Ligands
- CA, SO4
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 145 | 62% helix, 4% strand | P62161 |
| B | Voltage-dependent R-type calcium channel subunit alpha-1E peptide | protein | 17 | 88% helix, 0% strand | Q07652 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 190 | 0.51 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1336 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3BXL · Crystal structure of the R-type calcium channeL (CaV2.3) IQ domain and CA2+calmodulin… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07652 · AlphaFold monomer V2.0 prediction for voltage-dependent R-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62161
- Every structure of UniProt Q07652
- Elsewhere: RCSB PDB 3BXL · PDBe 3BXL · UniProt P62161 · UniProt Q07652
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