MolNFT v1 · #59325 · protein
Crystal structure of C-cbl-tkb domain complexed with its binding motif in SPROUTY2
3BUM · Protein sprouty homolog 2: “Crystal structure of C-cbl-tkb domain complexed with its binding motif in SPROUTY2”. X-ray diffraction, 4 pockets (best druggability 0.56). MolNFT v1 #59325 on GenesisL1: 3D structure, binding sites and…
- PDB
- 3BUM
- Type
- protein
- Length
- 313 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein sprouty homolog 2; E3 ubiquitin-protein ligase cbl
- EC
- 6.3.2.-
- UniProt
- O43597, P22681
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein sprouty homolog 2 | protein | 9 | 0% helix, 0% strand | O43597 |
| B | E3 ubiquitin-protein ligase cbl (EC 6.3.2.-) | protein | 304 | 59% helix, 8% strand | P22681 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.56 | 0.84 | 22 | empty |
| 2 | 57 | 0.39 | 0.80 | 15 | empty |
| 3 | 61 | 0.36 | 0.78 | 12 | empty |
| 4 | 61 | 0.31 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 579 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3BUM · Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2 · the same entry in another collection · chain A against A, TM-score 1.00
- P22681 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase cbl (P22681) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O43597 · AlphaFold monomer V2.0 prediction for protein sprouty homolog 2 (O43597) · a predicted model of the same protein · chain A against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43597
- Every structure of UniProt P22681
- Elsewhere: RCSB PDB 3BUM · PDBe 3BUM · UniProt O43597 · UniProt P22681
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