MolNFT v1 · #59306 · protein
Crystal structure of the insulin receptor kinase in complex with IRS2 krlb peptide
3BU3 · Insulin receptor subunit beta: “Crystal structure of the insulin receptor kinase in complex with IRS2 krlb peptide”. X-ray diffraction, 2 pockets (best druggability 0.70). MolNFT v1 #59306 on GenesisL1: 3D structure, binding sites…
- PDB
- 3BU3
- Type
- protein
- Length
- 311 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor subunit beta; Insulin receptor substrate 2
- EC
- 2.7.10.1
- UniProt
- P06213, P81122
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor subunit beta (EC 2.7.10.1) | protein | 297 | 36% helix, 19% strand | P06213 |
| B | Insulin receptor substrate 2 | protein | 14 | 21% helix, 36% strand | P81122 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 349 | 0.70 | 0.82 | 44 | empty |
| 2 | 90 | 0.40 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1074 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (phosphorylation).
Compared structures
- 3BU3 · Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P81122 · AlphaFold monomer V2.0 prediction for insulin receptor substrate 2 (P81122) · a predicted model of the same protein · chain B against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P81122
- Elsewhere: RCSB PDB 3BU3 · PDBe 3BU3 · UniProt P06213 · UniProt P81122
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