MolNFT v1 · #5917 · protein
Anabaena PCC7119 FERREDOXIN:FERREDOXIN-NADP+-reductase complex
1EWY · Ferredoxin-NADP reductase: “Anabaena PCC7119 FERREDOXIN:FERREDOXIN-NADP+-reductase complex”. X-ray diffraction, 2 ligands (FAD, FES), 13 pockets (best druggability 0.75). MolNFT v1 #5917 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1EWY
- Type
- protein
- Length
- 704 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferredoxin-NADP reductase; Ferredoxin I
- EC
- 1.18.1.2
- UniProt
- P21890, P0A3C8
- Ligands
- FAD, FES
- Pockets
- 13 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ferredoxin-NADP reductase (EC 1.18.1.2) | protein | 303 | 26% helix, 27% strand | P21890 |
| C | Ferredoxin I | protein | 98 | 13% helix, 30% strand | P0A3C8 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, C, B
- FES · Fe2/s2 (inorganic) cluster · ligand · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.75 | 0.84 | 59 | FAD |
| 2 | 111 | 0.75 | 0.95 | 27 | empty |
| 3 | 305 | 0.69 | 0.84 | 34 | empty |
| 4 | 295 | 0.68 | 0.83 | 34 | FAD |
| 5 | 101 | 0.66 | 0.90 | 27 | empty |
Interfaces
3 interfaces between chains.
- A–C · 823 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 767 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 586 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1EWY · Anabaena PCC7119 FERREDOXIN:FERREDOXIN-NADP+-reductase complex · the same entry in another collection · chain A against A, TM-score 1.00
- P21890 · AlphaFold monomer V2.0 prediction for ferredoxin--NADP reductase (P21890) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P0A3C8 · AlphaFold monomer V2.0 prediction for ferredoxin-1 (P0A3C8) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21890
- Every structure of UniProt P0A3C8
- Elsewhere: RCSB PDB 1EWY · PDBe 1EWY · UniProt P21890 · UniProt P0A3C8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.