MolNFT v1 · #59030 · protein

TRNA guanine transglycosylase V233G mutant PREQ1 complex structure

3BLD · Queuine tRNA-ribosyltransferase: “TRNA guanine transglycosylase V233G mutant PREQ1 complex structure”. X-ray diffraction, 2 ligands (PRF, ZN), 3 pockets (best druggability 0.61). MolNFT v1 #59030 on GenesisL1: 3D structure, binding…

PDB: 3BLD
Type: protein
Length: 348 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Queuine tRNA-ribosyltransferase
EC: 2.4.2.29
UniProt: P28720
Ligands: PRF, ZN
Pockets: 3 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Queuine tRNA-ribosyltransferase (EC 2.4.2.29)	protein	348	46% helix, 16% strand	P28720

Ligands and binding sites

PRF · 7-deaza-7-aminomethyl-guanine · ligand · chains A
ZN · Zinc ion · metal · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.61	0.83	29	PRF
2	143	0.40	0.73	16	empty
3	58	0.30	0.76	13	empty

Compared structures

3BLD · tRNA guanine transglycosylase V233G mutant preQ1 complex structure · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28720
Elsewhere: RCSB PDB 3BLD · PDBe 3BLD · UniProt P28720

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