MolNFT v1 · #58813 · protein
Structure of a poxvirus IFNGBP/IFNG complex
3BES · Interferon gamma: “Structure of a poxvirus IFNGBP/IFNG complex”. X-ray diffraction, 3 ligands (NAG, BMA, PO4), 3 pockets (best druggability 0.74). MolNFT v1 #58813 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3BES
- Type
- protein
- Length
- 383 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon gamma; Interferon-gamma binding protein C4R
- UniProt
- P01579, Q66793
- Ligands
- NAG, BMA, PO4
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Interferon gamma | protein | 133 | 68% helix, 0% strand | P01579 |
| R | Interferon-gamma binding protein C4R | protein | 250 | 20% helix, 41% strand | Q66793 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains R
- BMA · beta-D-mannopyranose · sugar
- PO4 · Phosphate ion · ion · 3 copies · chains L, R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1033 | 0.74 | 0.76 | 58 | empty |
| 2 | 90 | 0.39 | 0.77 | 18 | empty |
| 3 | 56 | 0.30 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- L–R · 686 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01579
- Every structure of UniProt Q66793
- Elsewhere: RCSB PDB 3BES · PDBe 3BES · UniProt P01579 · UniProt Q66793
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