MolNFT v1 · #58802 · protein
Crystal structure of sr protein kinase 1 complexed to its substrate ASF/SF2
3BEG · SERINE/THREONINE-protein kinase SRPK1: “Crystal structure of sr protein kinase 1 complexed to its substrate ASF/SF2”. X-ray diffraction, 1 ligand (ANP), 3 pockets (best druggability 0.81). MolNFT v1 #58802 on GenesisL1: 3D…
- PDB
- 3BEG
- Type
- protein
- Length
- 436 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase SRPK1; Splicing factor, ARGININE/SERINE-rich 1
- EC
- 2.7.11.1
- UniProt
- Q96SB4, Q07955
- Ligands
- ANP
- Pockets
- 3 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase SRPK1 (EC 2.7.11.1) | protein | 350 | 38% helix, 15% strand | Q96SB4 |
| B | Splicing factor, ARGININE/SERINE-rich 1 | protein | 86 | 23% helix, 27% strand | Q07955 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 978 | 0.81 | 0.82 | 79 | ANP |
| 2 | 214 | 0.53 | 0.78 | 27 | empty |
| 3 | 62 | 0.28 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1084 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3BEG · Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q96SB4 · AlphaFold monomer V2.0 prediction for srsf protein kinase 1 (Q96SB4) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q07955 · AlphaFold monomer V2.0 prediction for SERINE/ARGININE-rich splicing factor 1 (Q07955) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96SB4
- Every structure of UniProt Q07955
- Elsewhere: RCSB PDB 3BEG · PDBe 3BEG · UniProt Q96SB4 · UniProt Q07955
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