UniProt Q96SB4
SRSF protein kinase 1 (Q96SB4)
SRSF protein kinase 1 (UniProt Q96SB4), EC 2.7.11.1: 11 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96SB4
- Protein
- SRSF protein kinase 1
- EC
- 2.7.11.1
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 28 · 4 records with a druggable one
Structures
12 records of Q96SB4 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1WAK | X-ray structure of SRPK1 | x-ray diffraction | A | — | — |
| 1WAK | X-ray structure of SRPK1 | x-ray diffraction | A | — | — |
| 3BEG | Crystal structure of SR protein kinase 1 complexed to its substrate ASF/SF2 | x-ray diffraction | A | — | — |
| 3BEG | Crystal structure of sr protein kinase 1 complexed to its substrate ASF/SF2 | x-ray diffraction | A | — | — |
| 4WUA | Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340 | x-ray diffraction | A | — | — |
| 4WUA | Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340 | x-ray diffraction | A | — | — |
| 5MY8 | Crystal structure of SRPK1 in complex with SPHINX31 | x-ray diffraction | A | RXZ | 3 (best 0.71) |
| 5MY8 | Crystal structure of SRPK1 in complex with SPHINX31 | x-ray diffraction | A | RXZ | — |
| 6FAD | SR protein kinase 1 (SRPK1) in complex with the RGG-box of HSV1 ICP27 | x-ray diffraction | A, B, C, D | PO4 | 13 (best 0.81) |
| 6FAD | Sr protein kinase 1 (SRPK1) in complex with the rgg-box of HSV1 ICP27 | x-ray diffraction | A, B, C, D | PO4 | — |
| 7ZKS | SRPK1 in complex with inhibitor | x-ray diffraction | A | IXQ, CL | 3 (best 0.76) |
| Q96SB4 | AlphaFold monomer V2.0 prediction for srsf protein kinase 1 (Q96SB4) | predicted | A | — | 9 (best 0.81) |
Ligands
Experiment against prediction
- 4WUA chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.49 Å
- 4WUA chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.49 Å
- 6FAD chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.62 Å
- 6FAD chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.62 Å
- 7ZKS chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.72 Å
- 1WAK chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.94 Å
- 1WAK chain A against the predicted model Q96SB4: TM-score 0.99, RMSD 0.94 Å
- 6FAD chain B against the predicted model Q96SB4: TM-score 0.99, RMSD 0.77 Å
- 5MY8 chain A against the predicted model Q96SB4: TM-score 0.98, RMSD 1.02 Å
- 5MY8 chain A against the predicted model Q96SB4: TM-score 0.98, RMSD 1.02 Å
Elsewhere
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