MolNFT v1 · #58566 · protein
Human farnesyl diphosphate synthase complexed with mg and minodronate
3B7L · Farnesyl pyrophosphate synthetase: “Human farnesyl diphosphate synthase complexed with mg and minodronate”. X-ray diffraction, 2 ligands (M0N, MG), 1 pocket (best druggability 0.78). MolNFT v1 #58566 on GenesisL1: 3D structure…
- PDB
- 3B7L
- Type
- protein
- Length
- 343 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Farnesyl pyrophosphate synthetase
- EC
- 2.5.1.10
- UniProt
- P14324
- Ligands
- M0N, MG
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 75% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Farnesyl pyrophosphate synthetase (EC 2.5.1.10) | protein | 343 | 75% helix, 1% strand | P14324 |
Ligands and binding sites
- M0N · (1-hydroxy-2-imidazo[1,2-a]pyridin-3-ylethane-1,1-diyl)bis(phosphonic acid) · ligand · chains A
- MG · Magnesium ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 439 | 0.78 | 0.86 | 48 | MG, M0N |
Compared structures
- 3B7L · Human farnesyl diphosphate synthase complexed with MG and minodronate · the same entry in another collection · chain A against A, TM-score 1.00
- P14324 · AlphaFold monomer V2.0 prediction for farnesyl pyrophosphate synthase (P14324) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14324
- Elsewhere: RCSB PDB 3B7L · PDBe 3B7L · UniProt P14324
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